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Supercritical CO₂ Purification System

CHROMATOGRAPHY
Integrate supercritical CO2 purification into your process
Purify your molecules without toxic chemical solvents
A fast, cost-effective process
Separation of closely related molecules
Purification with supercritical CO2
is the guaranteed method
for separating molecules without using organic solvents.

Chromatography, a formidable purification and production tool

Finalize your purification process with supercritical CO2 chromatography, enabling you to separate, select and collect one or more molecules of interest from the preparative scale. It can also be used to analyze the composition of a complex mixture.

Whether you're in the testing or production phase

we have the solution

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Preparatory scale

SFC PREP

Standard range from 100ml to 2L

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Production scale

SFC PROD

Standard range from 2x5L to 2x100L

Separate Closely Related Molecules

Whether you are in the preparation or production phase
we have the solution
Semi prep
sfc 30
Information
Column diameter :
CO2 flow :
CO2 co-solvent :
30mm
Up to 150g/min
Up to 50ml/min
Prep
sfc 50
Information
Column diameter :
CO2 flow :
CO2 co-solvent :
50mm
Up to 1 000g/min
Up to 400ml/min
Prep
sfc 50
Information
Column diameter :
CO2 flow :
CO2 co-solvent :
100mm
Up to 2500g/min
Up to 600ml/min

SFC Process expertise
to bring your project to fruition

01.

Specifications

02.

Design

03.

Manufacturing

04.

Installation

05.

Support

The advantages of supercritical CO2 purification

Fast

It reduces the number of steps and therefore the cost of purification, by eliminating or greatly reducing post-processing steps such as the elimination of elution solvents.

Scalable

Our systems are designed to be modular, scalable and adaptable to your production needs. They are also designed from laboratory to industrial scale. industrial scale.

Productivity

Solvent management and reprocessing are greatly reduced, thus greatly reducing the OPEX and environmental cost of a process.

Own

Large quantities of samples can be purified while reducing or completely eliminating the consumption of toxic chemical solvents. CO2 is a natural, non-toxic, inert and odorless solvent, unlike petrochemical solvents.

Safe

Supercritical CO2 is a safe and effective solvent, without the risks associated with other solvents used for purification, such as volatile and potentially explosive organic solvents (like ethanol, for example). What’s more, supercritical CO2 can be easily separated and recycled, making it an environmentally-friendly and economical choice for purification.

Chromatography with SFC Process

SFC Process builds state-of-the-art, high-performance supercritical phase chromatography equipment for R&D laboratories and industrial scale-up. The solutions implemented by SFC Process enable a drastic reduction in the use of co-solvent, thanks to the development of chromatographic equipment capable of working on a range of CO2 densities never before evaluated.

Analyze Complex Mixture Composition

Do you have a specific need?

SFC Process has a research and development laboratory to carry out your feasibility studies in partnership with Reach Separation, which is equipped with the
SFC 30
and develop tomorrow’s technologies.

Would you like to test your biomass before taking the plunge? Our laboratory is equipped with several pilots, so we can offer you a top-quality service and full support for scale-up, from laboratory scale to pilot scale, producing your first batches.

Schedule your appointment

Discover how SFC Process will take your purification process into a new era

Book a meeting with our engineers and chemists, and together we’ll find the best solutions for setting up or improving your extraction process.

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Rated 4.5 out of 5
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What is chromatography used for?

Chromatography is based on the use of a supercritical fluid as the mobile phase or eluent. CO2, in its supercritical form, has density and hydrophobicity characteristics that can be modulated according to pressure. It’s these characteristics that come into play during SFC purification. As CO2 is a gas at atmospheric pressure and ambient temperature, the richer the eluent composition in CO2, the more economical it is to obtain “dry” compounds of interest.

An eco-friendly solution to purify molecules without solvents

Supercritical CO₂ chromatography is a cutting-edge separation technology used to purify molecules without solvents. At SFC Process, we integrate this clean and efficient method into comprehensive systems tailored to industrial requirements and environmental standards.

Using carbon dioxide in its supercritical state, this non-polluting chromatography technique drastically reduces the need for toxic organic solvents while maintaining high purification performance. It is a preferred alternative in demanding sectors such as pharmaceuticals, flavors, and fine chemicals.

Advanced technology to separate very similar molecules

One of the key strengths of supercritical CO₂ chromatography is its ability to separate very similar molecules that are difficult to isolate using conventional methods. With precise control over temperature, pressure, and flow, this process ensures fine, reproducible separations.

This capability makes it ideal for processing complex mixtures while increasing throughput and reducing cycle times. At SFC Process, we design customized equipment that maximizes the benefits of non-polluting chromatography and solvent-free molecular separation.

Safely and precisely collect the molecules that matter most

Systems developed by SFC Process allow you to collect molecules of interest with high purity and accuracy. Leveraging supercritical CO₂ chromatography, our systems automate the recovery of purified fractions while preserving molecular integrity.

Our technology supports both research labs and industrial-scale production with a range of capacity options:

  • The SFC 30, ideal for pilot runs and small batches

  • The SFC 50, for intermediate-scale processing

  • The SFC 100, designed for high-volume industrial use

By offering the ability to purify and collect molecules without solvents, we help improve process efficiency and product quality.

A reliable method to analyze complex mixtures

Supercritical CO₂ chromatography is also an excellent method to analyze the composition of complex mixtures. It offers a faster, cleaner, and more efficient alternative to traditional liquid chromatography, especially for thermally sensitive or solvent-incompatible compounds.

Used for both purification and quality control, this non-polluting chromatography solution enables accurate detection, separation, and collection of target molecules from natural or synthetic sources. Its analytical performance makes it a valuable asset for a wide range of industries.

In summary, supercritical CO₂ chromatography from SFC Process allows you to purify molecules without solvents, separate very similar molecules, collect molecules of interest, and analyze the composition of complex mixtures in a sustainable and high-performance way.
🎅🎄 6 supercritical CO₂ systems under the tree… for a greener industry in 2026!

Go ahead, grab your pens and write your letter to Santa—your ready-to-use supercritical CO₂ equipment could be waiting under the tree this year!

This year, we’re putting on our red hats to offer you an exclusive deal6 supercritical CO₂ systems in stock and ready for you!

Want to complete your projects on time, reduce toxic solvent use, or explore new processes? Get ahead for 2026 with our solutions—no compromise on quality or profitability!

🎁 Our “holiday special” catalog (100% serious):

  • SFC 30: The purification superstar (6 separators, 350 bar, 500 g/min)
  • SFD 1L: Next-gen drying (250 bar, 100 g/min)
  • SFE Lab 2L: The ultra-versatile lab system (1000 bar, 70 g/min)
  • SFE 2×5: The agile solution (380 bar, 30 kg/h)
  • SFE 2×25: Power and precision (380 bar, 125 kg/h)
  • SFE 2×100: The small giant of extraction (350 bar, 500 kg/h)