SFC — Preparative chromatography with supercritical CO₂

Develop your purification processes by integrating SFC

End-to-end support: from method development and POC to scale-up, commissioning, training, maintenance and technical support to secure your production.
Proven expertise: our specialists ensure the reliability and perfect reproducibility of your SFC processes.
Scale flexibility: a range of high-performance equipment to handle your volumes from grams to kilograms.
Compliance & Quality: an ISO 9001 certified system guaranteeing validation of your projects from food to pharmaceuticals.

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The advantages of SFC technology

Why choose SFC? A proven alternative to conventional preparative chromatography that combines unmatched separation finesse and control flexibility with significantly higher productivity.

SFC: up to 7× faster than conventional preparative liquid chromatography

Under equivalent conditions, the mobile phase in SFC flows at rates far higher than conventional liquid processes — a major productivity gain, illustrated by the achievable flow rates by column diameter.

SFC conditions: density at 120 bar and a ΔP of 30 bar.

Column diameter (mm)	Mobile phase flow rate (ml/min)
21.2	169
30	462
50	1,231
100	4,154
250	26,615

*Non-contractual data, provided for indicative purposes only.

Other strengths of SFC

Precise tuning through density

The density of the mobile phase can be finely tuned via pressure and temperature, providing exceptional flexibility in controlling separations.

Enhanced selectivity and resolution

SFC efficiently leverages stationary phases with very fine particle sizes (3, 5 and 10 microns), dramatically increasing the selectivity of your separations.

SFC: a proven technology that addresses
the challenges of low-cost industrial purification

Supercritical CO₂ chromatography integrates sustainably into your production lines and goals.

Our approach guarantees the stability of the purification process and secures operational continuity to make performance last over time.

Cost mastery

Cut your operating costs: less co-solvent, longer-lasting stationary phase and simpler processes.

Reproducible

Achieve reliable, consistent results thanks to ultra-stable processing conditions.

Optimised performance

Speed up your cycles and process larger quantities in a single run.

Sustainable simplicity

Reduce your use of petroleum-based solvents and minimise downstream processing.

A solution designed for
high-purity purification (> 95%)

Each industry has its own specifics, quality standards and regulatory requirements.

Our solutions fit into these environments with an approach tailored to the technical, regulatory and operational demands of each application.

Pharmaceuticals

Purification of peptides, chiral molecules, fat-soluble vitamins, steroids, enzymes and proteins.

Cosmetics & Fragrance

Purification of carotenoids, peptides, fatty acids, volatile compounds and monoterpenes.

Nutraceuticals & Food

Purification of omega-3, astaxanthin, cordycepin and other high-value molecules.

Medical cannabinoids

Purification of THC, CBD and minor cannabinoids.

Together, let's build
your success

We are structured to support large-scale projects with an integrated approach, a long-term vision and the ability to meet the demands of the most advanced industrial environments.

Application laboratory

Test, validate and develop your methods in our in-house application laboratory before scaling to industrial deployment.

Our team of experts guides you through technical choices and the conditions for transferring to production.

Expertise & project management

Beyond the technology, we deliver structured guidance designed to secure every step of development and industrialisation.

Projects are driven by experienced managers with deep knowledge of industrial environments.

Long-term partnership

We are structured to support complex industrial projects, offering long-term commitment and vision.

Complete equipment range

SFC Process offers a complete range of equipment, from semi-preparative R&D systems to the most complex industrial-scale solutions.

Quality management

Our quality organisation is built to meet the most demanding industrial and regulatory standards.

ISO 9001 certified GMP environment expertise Documentation, traceability and quality requirements tailored to regulated contexts

Support & operational continuity

We provide long-term support through a dedicated organisation covering service, maintenance and installation monitoring.

This organisation ensures operational continuity, equipment availability and lasting performance over time.

Photo du labo

SFC — Preparative chromatography with supercritical CO₂

The advantages of SFC technology